Mechanism of action
PrVELPHORO® is a mixture of polynuclear iron (III)-oxyhydroxide (pn-FeOOH), sucrose, and starches.
Phosphate binding takes place by ligand exchange between hydroxyl groups and/or water and the phosphate ions throughout the physiological pH range of the GI tract.
Pharmacodynamics
In vitro studies have demonstrated a robust phosphate binding capacity of VELPHORO over the physiological pH range of the GI tract.1*†
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EFFICACY DATA
SAFETY AND TOLERABILITY PROFILE
DOSING AND ADMINISTRATION
* Clinical significance has not been established.
† pH range of the GI tract: 1.2-7.5.
GI = gastrointestinal.
† pH range of the GI tract: 1.2-7.5.
GI = gastrointestinal.
- Reference:
- 1. VELPHORO Product Monograph. Otsuka Canada Pharmaceutical Inc.
Important Safety Information
